Going to have to recommend Dan Vs.
It's on the Hub, a channel you ponyfans might be familiar with. I noticed the thread starter said he wasn't always in the mood of MLP's "brand of entertainment," so I thought he might like the show, since it's sort of MLP's foil.
MLP is about cute little ponies making friends and and resolving your differences peacefully in situations both mundane and fantastical, while Dan Vs. is about a rageaholic little man making enemies and setting out to get swift revenge against foes in situations both mundane and fantastical, oftentimes leaving a path of destruction in his wake. So it's sort of the yang to MLP's yin.
http://www.youtube.com/watch?v=RGs32MUBBnI...349F67E5B461C96 --- Episode clip
http://www.youtube.com/watch?v=l0n1WGHLmCw ---- Dan Vs. Pinkie Pie
Other shows I enjoy are Wakfu (French cartoon, based off an MMORPG with a SRPG playstyle,) Thundercats (season two starts later this month!) Adventure Time, Gumball, Regular Show.
Also, I guess I'm the only other guy on this thread who liked Invader Zim....
Is anyone looking forward to The Legend of Korra, the sequel to the Last Airbender series? I'm trying not to get myself too hyped up for it, but every clip I see makes it look better and better.